Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice

Gm614 Protects Germinal Center B Cells From Death by Suppressing Caspase-1 Transcription in Lupus-Prone Mice

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Only a few signaling pathways have been reported in germinal center (GC) B-cell proliferation and death.In this study, we showed that a novel uncharacterized Gm614 protein is highly expressed in GC B cells from lupus-prone mice.Critically, ablation of this GC tonic shower cap B-cell-specific Gm614 promoted GC B-cell death and mitigation of autoimmune symptoms, whereas overexpression protected GC B cells from death and exacerbated autoimmune symptoms.We demonstrated that mechanistically, nuclear-localized Gm614 reduced caspase-1 el reformador tequila anejo expression in GC B cells by binding with caspase-1 promoter to suppress its activation.

Our results suggest that Gm614 protects GC B cells from death by suppressing caspase-1 transcription in autoimmune diseases.This may provide some hints for targeting the cell proliferation involved in autoimmune diseases.